It is believed that modern humans like you and I first originated on the Earth around 50,000 years ago in Africa. These modern humans are referred to by historians as Homo sapiens sapiens. Within just a few thousand years these modern humans had spread to every continent across the entire planet, and onto many islands.
As Homo sapiens sapiens migrated outward from Africa, it is believed that they wiped out Neanderthals, either by absorbing them through intermarriage, or by destroying them through war and competition.
The Egyptians invented toothpaste around 3000 B.C.