By the late 1500s A.D., the center of the Renaissance in Italy began to shift from Rome to the more wealthy city-state of Venice. Venice was located in the Mediterranean Sea among hundreds of tiny islands on the northeast edge of the Italian Peninsula. Its location made it ideal for trade.
Many in Venice grew wealthy, which allowed them to afford the finer pleasures of art and the humanities. Their money attracted the attention of many of the artists, writers and scholars in Rome. There was more money in Venice than in Rome, and as a result, it was easier for a humanist to make a living in Venice.
Venice quickly became world famous for the high quality of art and literature that they were producing.
The difference between a helping hand and an outstretched palm is a twist of the wrist.